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Functional microspheres

Biostable or biodegradable microspheres with protein or polysaccharide coatings and growth factor delivery

Biostable or biodegradable microspheres can be used as a three-dimensional environment for cell culture. Cells can be easily separated from the 3D support after culture. Microspheres are coated with bioactive molecules fixed to their surface by covalent bonds through flexible spacers. On the other hand the microspheres can deliver drugs or growth factors with a programmed kinetics.


Chondrocytes cultured in a 3D environment formed by gelatin microspheres.


Acrylic microspheres with or without a heparin coating.

More information:

D.M. García Cruz, V. Sardinha, J.L. Escobar Ivirico, J.F. Mano, J.L. Gómez Ribelles
Gelatin microparticles aggregates as three-dimensional scaffolding system in cartilage engineering
Journal of Materials Science. Materials in Medicine 24(2), 503-513 (2013)

N. García-Giralt, D.M. García Cruz, X. Nogues, J.L. Escobar Ivirico, J.L. Gómez Ribelles
Chitosan microparticles gel for "In vitro" 3D culture of human chondrocytes
RSC Advances 3, 6362-6368 (2013)

Piezoelectric microspheres containing or not magnetic nanoparticles are used for electro-mechanical stimulation of cells during culture in a 3D support.

More information:

D. M. Correia, R. Gonçalves, C. Ribeiro, V. Sencadas, G. Botelho, J. L. Gomez Ribelles, S. Lanceros-Méndez
Electrosprayed poly(vinylidene fluoride) microspheres for tissue engineering applications
RSC Advances 4, 33013-33021 (2014)

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The combination of microfracture of subchondral bone and an injectable supporting material induces regeneration of articular cartilage defects in a rabbit knee model. A work in collaboration with the group of Dr. Carmen Carda in INCLIVA, Valencia.

Contact information:

José Luis Gómez Ribelles