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Prosthesis for tendon and ligament

New biodegradable and regenerative prosthesis for tendon and ligament

Tendon 2

We have patented a new prosthesis for tendon and ligament. The prosthesis is made up by a hollow braid of biodegradable material, reproducing the mechanical features of native tendon or ligament. This braid is coated with hyaluronan in order to isolate it from the surrounding tissues, avoiding any adherence.

Inside the braid is injected a blend of biodegradable microparticles, stem cells and eventually growth factors. The objective is to promote the regeneration of tendinous or ligamentous tissue meanwhile the degradation of braid and microparticles occurs.

We have carried out cell cultures in vitro by mechanically stimulating the prosthesis, and our results reveal a proliferation and alignment of cells in the direction of the applied stimuli.

This prosthesis has been patented and several papers have been published. Actually, the next step to continue this work would be to confirm the effect of mechanical stimulation over the cell culture and to test the prosthesis with in vivo tests.

Tendon 2


Jorge Más Estellés

Tendon 2

More information:

Araque Monrós, MC (2013) Desarrollo de una prótesis regenerativa de tendón. PhD Theses. Universitat Polit├Ęcnica de Valencia, https://riunet.upv.es/handle/10251/30313.

Araque-Monrós MC, Gamboa-Martínez TC, Gil Santos L, Gironés Bernabé S, Monleón Pradas M, Más Estellés J (2013) New concept for a regenerative and resorbable prosthesis for tendon and ligament: Physicochemical and biological characterization of PLA-braided biomaterial. J Biomed Mater Res Part A 101A:3228-3237. DOI: 10.1002/jbm.a.34633. https://riunet.upv.es/bitstream/handle/10251/43271/2013%20JBMRA%20Riunet.pdf

Araque-Monrós MC, García Cruz DM, Escobar Ivirico JL, Más Estellés J, Monleón Pradas M (2011) Injectable biodegradable microspheres as cell support for tissue regeneration. Histol Histopathol 26(1):48.

Araque Monrós C, Gil Santos L, Gironés Bernabé S, Más Estellés J, Monleón Pradas M (2011) Procedimiento de obtención de una prótesis biodegradable. Patent n° P201130919.

Araque-Monrós MC, Vidaurre A, Gil Santos L, Gironés Bernabé S, Monleón Pradas M, Más Estellés J (2013) Study of the degradation of a new PLA braided biomaterial in buffer phosphate saline, basic and acid media, intended for the regeneration of tendons and ligaments. Polym Degrad Stabil 98(9):1563-1570. https://riunet.upv.es/bitstream/handle/10251/45052/V%20AUTOR%202013%20PDS.pdf?sequence=2&isAllowed=y